Job Description Summary

Seeking highly motivated individuals for staff scientist positions in neuroimmunology for projects that encompasses basic and translational research.

Work in the laboratory is centered around the complement system and neuroinflammatory mechanisms. Ongoing projects involve investigating acute and chronic neuroimmune responses occurring after stroke or after different types of traumatic brain injury, including the long-term neurodegenerative sequalae of injury. For example, one project is focused on traumatic brain injury as a risk factor for Alzheimer’s Disease. Another project investigates pathogenic mechanisms of postnatal hemorrhagic stroke and neurodevelopmental consequences. Studies utilize various mouse models, and the laboratory is also developing several novel transgenic animals for these studies. Techniques currently utilized include advanced microscopy, cellular and molecular immune profile analysis, high dimensional analyses, and detailed assessments of motor and cognitive functions. The laboratory is also involved in the development (and commercialization) of novel therapeutic approaches, and has been a leader in the development of novel targeted complement inhibitory strategies.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Research Grant

Cost Center

CC000981 COM M&I Operations CC

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

$0 - $0 - $0

Scheduled Weekly Hours

40

Work Shift

Job Description

Lead a project related to above described work, perform experimental procedures relevant to project. This will involve animal surgery in the context of mouse models of stroke and traumatic brain injury and determination of acute and chronic outcomes in terms of pathology and behavioral analysis. 35%E

Analysis and interpretation of data. Following collection of brain samples after murine stroke or traumatic brain injury, the preparation of brain section for microscopic analysis. Types of analysis to include confocal imaging, super-resolution imaging and cellular and molecular immune profile analysis. Additional analysis of collected samples will include high dimensional analyses such as RNA seq, spatial transcriptomics and mass cytometry. 35%E

Assist with projects of other lab personnel in related projects as required. Will involve similar types of analyses to those listed above. Assist with editing manuscripts arising from projects that are led by other personnel in the lab. 15%

Keep all records and lab notebook up to date, including the use of Lab Archives. Assist the lab manager with any compliance issues and animal protocols (eg.IACUC). Write manuscripts. Review and keep abreast of literature. 15%

MUSC is located in the beautiful historic district of Charleston, regularly ranked the best small city destination in the U.S. It is also bounded by the Atlantic Ocean and beautiful beaches to the east, and national forests and wildlife refuges to the north and south. MUSC is the state’s top-ranked medical center and leads the state in research funding. For general information on the University and Research, see: https://research.musc.edu/our-research/areas and https://medicine.musc.edu.

For further information or to apply (CV and names of 3 referees), please contact:
Dr. Stephen Tomlinson: tomlinss@musc.edu

MUSC Minimum Training and Experience

A Ph.D., M.D. or equivalent with two years postdoctorate experience.

Additional Job Description

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 30 lbs., unassisted. (Frequent) Ability to lift objects, up to 30 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 30 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 50 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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