Job Description Summary

Dr. Toros Dincman at the Medical University of South Carolina, in collaboration with the Laboratory of Dr. Philip Howe, is seeking applicants for a Research Specialist I position. Responsibilities of this position will include performing experiments involving molecular biology, cell culture and biochemical assays, laboratory mice, and data analysis. Prior experience with in vitro work is preferred. Research interests focus on the role of RNA-Binding Proteins (RBP) and their impact on Colorectal Cancer (CRC) biology. Specifically, utilizing relevant pre-clinical CRC models, we seek to uncover novel pathways that involve RBP mutations and expression changes which influence CRC progression and therapeutic response. This work is facilitated by a highly collaborative laboratory group with access to state-of-the-art scientific equipment.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Research Grant

Cost Center

CC000970 COM DOM Hematology/Oncology CC

Pay Rate Type

Hourly

Pay Grade

University-04

Pay Range

$29,061 - $41,415 - $53,769

Scheduled Weekly Hours

40

Work Shift

Day (United States of America)

Job Description

Job Duties:

35% - Experiments investigating cellular and molecular mechanisms of RBP impact on CRC.

• Cell culture

• Utilizing cell and molecular biology techniques including protein, RNA and DNA isolation and separation, Western blotting, PCR, qPCR, flow cytometry, Co-Immunoprecipitation, RNA Immunoprecipitation, CRISPR-Cas9, molecular cloning, transfections and gene expression assays, cell proliferation and apoptosis assays, electroporation, confocal microscopy, and immunofluorescence staining

• Developing and optimizing protocols for in vitro experiments

35% - Data analysis and presentation

• Graphing and visualization of data with software including Graphpad Prism, FlowJo, Snapgene, Biorender, Microsoft Powerpoint, Microsoft Excel, and Adobe Illustrator

• Presenting data during lab meetings

• Preparing publication quality figures, may be involved in writing of manuscripts

• Efforts will directly contribute to grant applications and manuscripts

15% - Small laboratory animals

• Collection and processing of tissues for downstream analysis

• Monitoring of tumor growth with in vivo imaging

• Oversee overlapping experiments

15% - General laboratory responsibilities

• Maintenance of laboratory instruments, supplies, and equipment

• Maintenance of laboratory notebooks and records related to protocols, policy and regulation

• Assist with ordering reagents and supplies

Preferred Experience & Additional Skills: A bachelor’s degree in chemistry, biology, or other natural, life or health care science and ideally at least one-year of work experience related to the assigned research area. Previous experience in cell culture, molecular biology, and/or skills listed under Job Duties below is preferred.

MUSC Minimum Training and Experience Requirements:

A high school diploma and two years work experience in a clinical or research setting; a bachelor's degree in chemistry, biology, or other natural, life or health care science may be substituted for the two years of required experience.

MUSC Physical Requirements:

(Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift)

Ability to perform job functions in an upright position. (Frequent)
Ability to perform job functions in a seated position. (Continuous)
Ability to perform job functions while walking/mobile. (Frequent)
Ability to climb, using step stool. (Infrequent)
Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent)
Ability to work in confined/cramped spaces. (Continuous)
Ability to bend at the waist. (Frequent)
Ability to twist at the waist. (Frequent)
Ability to fully use both hands/arms. (Continuous)
Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent)
Ability to fully use both legs. (Frequent)
Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent)
Ability to maintain good olfactory sensory function/distinction. (Continuous)
Ability to lift materials up to 20 lbs., unassisted. (Infrequent)
Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent)
Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent)
Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/
Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent)
Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent)
Ability to push/pull file boxes from one location to another at floor level. (Frequent)
Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent)
Ability to perform gross motor functions with frequent fine motor movements. (Continuous)
Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous)
Ability to match or discriminate between colors, normally. (Continuous)
Ability to hear and recognize various alarms emitting from work area systems. (Continuous)
Ability to hear and/or understand conversations. (Continuous)
Ability to work in a darkroom for processing film, etc. (Continuous)
Ability to be qualified physically for respirator use, initially and annually. (Continuous)

Additional New Requirements:
Ability to work rotating shifts as required.
Ability to work overtime as required.
Ability to learn and use new processes, tools and equipment as required.

Additional Job Description

Minimum Requirements: A high school diploma and two years work experience in a clinical or research setting; a bachelor's degree in chemistry, biology, or other natural, life or health care science may be substituted for the two years of required experience. Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous) Ability to match or discriminate between colors, normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film, etc. (Continuous) Ability to be qualified physically for respirator use, initially and annually. (Continuous) Additional New Requirements: Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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