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UNIV - Research Specialist III- Bioinformatician - Department of Neuroscience

Medical University of South Carolina

Medical University of South Carolina

Charleston, SC, USA
Posted on Tuesday, April 25, 2023
  • R-0000012279
  • Charleston, South Carolina
  • Laboratory
  • Clinical & Research Support Services
  • Full Time

Job Description Summary

The brand-new MUSC Bioinformatics Core (BioCM) is seeking a superb bioinformatician to
develop scientific tools for single cell multiomics and other next-generation sequencing methods.
Under the supervision and guidance of BioCM staff and Dr. Stefano Berto, the bioinformatician
will contribute to NGS analysis projects, and they will work closely with oncologists, biologists,
and geneticists across HCC and MUSC developing, implementing, and applying computational
tools to analyze, visualize and integrate local and independent next generation sequencing data.
The successful candidate will need to be able to write original code for specific applications and
also be able to use and tailor existing software tools and analytic pipelines.
The bioinformatician will be expected to write and publish methodological articles, e.g. on new
methods, benchmarking, or improvements in data interpretation. They will have the opportunity
to present results in national and international conferences. They will also be encouraged to
collaborate in biology-motivated projects in the lab and with external collaborators. The
bioinformatic projects will be defined together with Dr. Stefano Berto, based on the
bioinformatician interests and competences and the needs of the BioCM projects. Most of their
time will be dedicated to research, but a contribution to supervising is expected, including the
possibility of supervising students or other postdocs.


Medical University of South Carolina (MUSC - Univ)

Worker Type


Worker Sub-Type​

Research Grant

Cost Center

CC000984 COM NEURO RES Operations CC

Pay Rate Type


Pay Grade


Pay Range

$43,030 - $61,323 - $79,616

Scheduled Weekly Hours


Work Shift

Job Description

Job Duties:

• Under moderate to minimal supervision, lead bioinformatics design and analyses of genetics and transcriptomics datasets from bulk and single-cell RNA sequencing and their integration with other data sources and -omics data (35%)

• Lead the design and development of software, databases, and pipelines (e.g. nextflow, snakemake) for analyzing and manipulating research data applications including expertise with simple programming using R/Python or Java, statistical programming, web-development, and database query through SQL (30%).

• Provide bioinformatics support to different research groups at the MUSC and provide guidance/supervision to group-associated bioinformaticians (15%).

• Provides direct technical support and helps guide, implement, and maintain further improvements to bioinformatics software, databases, and interfaces and works with the entire bioinformatics team to diagnose and fix related issues (10%).

• May assist in grant and other funding applications, as necessary and appropriate (5%).

• Performs other responsibilities as required (5%).

MUSC Minimum Training and Experience Requirements:

A bachelor's degree in chemistry, biology, or other natural, life or health care science directly related to the assigned area of research and two years advanced journey-level work experience in a clinical or research setting.

Preferred Skills:

• Experience in applied NGS data analysis such as Transcriptomics (RNA-seq, scRNA-seq), Genomics (WGS/WES) and Epigenomics (WGBS, ChIP-seq, ATAC-seq); additional experience with other omics methods is a plus.

• Demonstrable experience in programming languages required for data analysis (R and/or Python); Experience with other programming languages is of advantage.

• A solid foundation in statistics; Experience with advance statistics (e.g. machine learning, deep learning) is essential.

• Good working knowledge of Unix/Linux/MacOS.

• Knowledge and use of cloud computing environments, specifically Amazon Web Services and familiarity with cluster (HPC) compute environments.

• Desirable: Experience building and maintaining bioinformatics tools/pipelines; experience with scientific software development is of advantage

Physical Requirements:

(Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift)

Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent)

Ability to work indoors. (Continuous)

Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent)

Ability to twist at the waist. (Frequent)

Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous)

Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous)

Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous)

Ability to maintain tactile sensory functions. (Continuous)

Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent)

Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent)

Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent)

Ability to maintain 20/40 vision, corrected. (Continuous)

Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous)

Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous)

Ability to maintain hearing acuity, with correction. (Continuous)

Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent)

Additional New Requirements:

Ability to obtain and maintain a valid drivers license. Computer literacy.

Ability to work rotating shifts as required. Ability to work overtime as required.

Ability to learn and use new processes, tools and equipment as required.

Additional Job Description

A bachelor's degree in chemistry, biology, or other natural, life or health care science directly related to the assigned area of research and two years advanced journel-level work experience in a clinical or research setting.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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